Biodegradable Thermogelling Polymers: Working Towards Clinical Applications
As society ages, aging medical problems such as organ damage or failure among senior citizens increases, raising the demand for organ repair technologies. Synthetic materials have been developed and applied in various parts of human body to meet the biomedical needs. Hydrogels, in particular, have found extensive applications as wound healing, drug delivery and controlled release, and scaffold materials in the human body. The development of the next generation of soft hydrogel biomaterials focuses on facile synthetic methods, efficacy of treatment, and tunable multi-functionalities for applications. Supramolecular 3D entities are highly attractive materials for biomedical application. They are assembled by modules via various non-covalent bonds (hydrogen bonds, p–p stacking and/or van der Waals interactions). Biodegradable thermogels are a class of such supramolecular assembled materials. Their use as soft biomaterials and their related applications are of interest.
References:
1 Loh, X. J. et al. New Thermogelling Poly(ether carbonate urethane)s Based on Pluronics F127 and Poly(polytetrahydrofuran carbonate). Journal of Applied Polymer Science 131, doi:10.1002/app.39924 (2014).
2 YE, E., DEEN, G. R. & LOH, X. J. THERMOGELLING COPOLYMERS FOR MEDICAL APPLICATIONS. Journal of Molecular and Engineering Materials 01, 1330002, doi:doi:10.1142/S2251237313300027 (2013).
3 Loh, X. J., Yee, B. J. H. & Chia, F. S. Sustained delivery of paclitaxel using thermogelling poly(PEG/PPG/PCL urethane)s for enhanced toxicity against cancer cells. Journal of Biomedical Materials Research Part A 100A, 2686-2694, doi:10.1002/jbm.a.34198 (2012).
4 Loh, X. J., Guerin, W. & Guillaume, S. M. Sustained delivery of doxorubicin from thermogelling poly(PEG/PPG/PTMC urethane)s for effective eradication of cancer cells. Journal of Materials Chemistry 22, 21249-21256, doi:10.1039/c2jm33777k (2012).
5 Nguyen, V. P. N., Kuo, N. Y. & Loh, X. J. New biocompatible thermogelling copolymers containing ethylene-butylene segments exhibiting very low gelation concentrations. Soft Matter 7, 2150-2159, doi:10.1039/c0sm00764a (2011).
6 Loh, X. J., Vu, P. N. N., Kuo, N. Y. & Li, J. Encapsulation of basic fibroblast growth factor in thermogelling copolymers preserves its bioactivity. Journal of Materials Chemistry 21, 2246-2254, doi:10.1039/c0jm03051a (2011).
7 Loh, X. J., Peh, P., Liao, S., Sng, C. & Li, J. Controlled drug release from biodegradable thermoresponsive physical hydrogel nanofibers. Journal of Controlled Release 143, 175-182, doi:10.1016/j.jconrel.2009.12.030 (2010).
8 Loh, X. J., Cheng, L. W. I. & Li, J. in Modern Trends in Polymer Science-Epf 09 Vol. 296 Macromolecular Symposia (eds F. Stelzer & E. Wiesbrock) 161-169 (2010).
9 Loh, X. J., Goh, S. H. & Li, J. Biodegradable Thermogelling Poly (R)-3-hydroxybutyrate -Based Block Copolymers: Micellization, Gelation, and Cytotoxicity and Cell Culture Studies. Journal of Physical Chemistry B 113, 11822-11830, doi:10.1021/jp903984r (2009).
10 Loh, X. J. et al. Biodegradable thermogelling poly(ester urethane)s consisting of poly(lactic acid) - Thermodynamics of micellization and hydrolytic degradation. Biomaterials 29, 2164-2172, doi:10.1016/j.biomaterials.2008.01.016 (2008).
11 Loh, X. J. & Li, J. Biodegradable thermosensitive copolymer hydrogels for drug delivery. Expert Opinion on Therapeutic Patents 17, 965-977, doi:10.1517/13543776.17.8.965 (2007).
12 Loh, X. J., Goh, S. H. & Li, J. New biodegradable thermogelling copolymers having very low gelation concentrations. Biomacromolecules 8, 585-593, doi:10.1021/bm0607933 (2007).
As society ages, aging medical problems such as organ damage or failure among senior citizens increases, raising the demand for organ repair technologies. Synthetic materials have been developed and applied in various parts of human body to meet the biomedical needs. Hydrogels, in particular, have found extensive applications as wound healing, drug delivery and controlled release, and scaffold materials in the human body. The development of the next generation of soft hydrogel biomaterials focuses on facile synthetic methods, efficacy of treatment, and tunable multi-functionalities for applications. Supramolecular 3D entities are highly attractive materials for biomedical application. They are assembled by modules via various non-covalent bonds (hydrogen bonds, p–p stacking and/or van der Waals interactions). Biodegradable thermogels are a class of such supramolecular assembled materials. Their use as soft biomaterials and their related applications are of interest.
References:
1 Loh, X. J. et al. New Thermogelling Poly(ether carbonate urethane)s Based on Pluronics F127 and Poly(polytetrahydrofuran carbonate). Journal of Applied Polymer Science 131, doi:10.1002/app.39924 (2014).
2 YE, E., DEEN, G. R. & LOH, X. J. THERMOGELLING COPOLYMERS FOR MEDICAL APPLICATIONS. Journal of Molecular and Engineering Materials 01, 1330002, doi:doi:10.1142/S2251237313300027 (2013).
3 Loh, X. J., Yee, B. J. H. & Chia, F. S. Sustained delivery of paclitaxel using thermogelling poly(PEG/PPG/PCL urethane)s for enhanced toxicity against cancer cells. Journal of Biomedical Materials Research Part A 100A, 2686-2694, doi:10.1002/jbm.a.34198 (2012).
4 Loh, X. J., Guerin, W. & Guillaume, S. M. Sustained delivery of doxorubicin from thermogelling poly(PEG/PPG/PTMC urethane)s for effective eradication of cancer cells. Journal of Materials Chemistry 22, 21249-21256, doi:10.1039/c2jm33777k (2012).
5 Nguyen, V. P. N., Kuo, N. Y. & Loh, X. J. New biocompatible thermogelling copolymers containing ethylene-butylene segments exhibiting very low gelation concentrations. Soft Matter 7, 2150-2159, doi:10.1039/c0sm00764a (2011).
6 Loh, X. J., Vu, P. N. N., Kuo, N. Y. & Li, J. Encapsulation of basic fibroblast growth factor in thermogelling copolymers preserves its bioactivity. Journal of Materials Chemistry 21, 2246-2254, doi:10.1039/c0jm03051a (2011).
7 Loh, X. J., Peh, P., Liao, S., Sng, C. & Li, J. Controlled drug release from biodegradable thermoresponsive physical hydrogel nanofibers. Journal of Controlled Release 143, 175-182, doi:10.1016/j.jconrel.2009.12.030 (2010).
8 Loh, X. J., Cheng, L. W. I. & Li, J. in Modern Trends in Polymer Science-Epf 09 Vol. 296 Macromolecular Symposia (eds F. Stelzer & E. Wiesbrock) 161-169 (2010).
9 Loh, X. J., Goh, S. H. & Li, J. Biodegradable Thermogelling Poly (R)-3-hydroxybutyrate -Based Block Copolymers: Micellization, Gelation, and Cytotoxicity and Cell Culture Studies. Journal of Physical Chemistry B 113, 11822-11830, doi:10.1021/jp903984r (2009).
10 Loh, X. J. et al. Biodegradable thermogelling poly(ester urethane)s consisting of poly(lactic acid) - Thermodynamics of micellization and hydrolytic degradation. Biomaterials 29, 2164-2172, doi:10.1016/j.biomaterials.2008.01.016 (2008).
11 Loh, X. J. & Li, J. Biodegradable thermosensitive copolymer hydrogels for drug delivery. Expert Opinion on Therapeutic Patents 17, 965-977, doi:10.1517/13543776.17.8.965 (2007).
12 Loh, X. J., Goh, S. H. & Li, J. New biodegradable thermogelling copolymers having very low gelation concentrations. Biomacromolecules 8, 585-593, doi:10.1021/bm0607933 (2007).